Thursday, March 25, 2010

Soo Last Week, or, I Matched!

I was on the news. Or my class was on the news. You might not know, but we're kind of a big deal.


I wish I could embed the video on that page, but I'm not that savvy. The main reason is that I would like to ask one question: who in the world writes for these TV newscasters? They should all be fired. I mean, take the opening line of that story: "It's called medicine's own March Madness." Really? Who calls it that? Not only is that not factual, it's not even catchy.

In other news, I'm headed *gasp* back to Utah. I will spend the next three years as a Family Medicine resident at McKay-Dee hospital in Ogden, though I do plan to live in the SLC.

In other, other news, I leave to start my bike ride in less than 36 hours. Not that I'm stressed. Wish me luck.

Sunday, March 21, 2010

My Boring Life, or, For Google's Eyes Only

I recently presented this paper at a History of Medicine conference in KY. I enjoyed writing the paper. Sort of. I enjoyed the conference. Sort of. It made me very glad I am not a Ph.D historian, because, while I enjoyed talking with them, I asked one what his emphasis was on. "Empathy," was his reply. Anything related to that word, which was only first introduced in the 20th century, believe it or not.

That is my way of saying that you, my average reader, will probably not enjoy this post whatsoever. I'd be delighted if you prove me wrong, but this is something of an esoteric, dry paper on medical philosophy.

So, only because Google is good about indexing everything, and this doesn't stand a chance of being published elsewhere, I thought I would post this article so someone, somewhere, sometime, might read this and get a little help on his or her research paper. Just remember that I didn't talk about Ibn al-Nafis in my introduction of Harvey. If you are doing a more exhaustive work on Harvey himself, you should read about him as he did present a logical discussion of the heart and continuous circulation in the 13th C and Harvey may or may not have read al-Nafis's writings. But the history of Harvey wasn't really the point of my paper.

The <> markings are where the slide was advanced.



William Harvey, “The Book of Nature,” and Modern Medical Thought

Bryce K. Peterson


Wm Harvey, Baldness & Ulcers

<>

Briefly, my talk will have an introduction, then we’ll talk about the history preceding Harvey, then Harvey himself, then we will talk about two other medical discoveries.

Introduction

<> This is a picture of Frog Basin in Northern Idaho, one of the more beautiful places on Earth. If you were to hike over this ridge, you would be met, not by a view of the ocean, the city, or any other prize signifying the end of the journey. Instead, you would be met, <> with a new view of more beauty, but one that differs in the details. New vistas can emerge as we are raised by the vision of those who have gone before. Giant’s shoulders are required to stand upon to climb to new heights. <>Einstein required Newton; Martin Luther King, Jr. needed Gandhi. As thorough readings of history reveal, few ideas are completely original, or outstandingly revolutionary. So it was with the introduction by William Harvey in the 17th century of the circulation of the blood. Built upon a long, solid history of medicine, and on the backs of others mining for new knowledge <>, Harvey was then able to unearth the stone, which, according to the Kenneth Franklin edition of De motu cordis, is “the most important work in the history of medicine” (Franklin, flap).

<> Occasionally, however, these new discoveries lead to conclusions that are not correct, such as with the 17th C advent of telescopes leading to the 19th C (erroneous) discovery of canals on Mars, quite the engineering feat of the intelligent Martians; similar such blunders have occurred in medicine, whether in topics as superficial as baldness or as serious as peptic ulcer disease. While the work of men and women in times past is essential for forward progress, healthy skepticism must remain for new discoveries.

While striking the balance between acceptance and skepticism when approaching new scientific findings can clearly be difficult, it is of vital importance in our approach to not only the patient, but the world. Although this is a topic being approached from a historical perspective, this talk is not intended to be a rigorous historical treatment; it is, rather, meant to be a thought piece that provokes conversation about the consideration a clinician must use when examining new information from any source, as well as remembering the human filter through which that information flows, affecting our own view of ideas, both old and new.

Ancient Medicine

<> To better understand the view that William Harvey had of medicine and the world, it is important to first briefly recall the historical context in which Harvey lived. <> As an obvious medical phenomenon the blood itself was given attention by the earliest ancestors of medical scientists. Many theories were given, but predominant in the Middle Ages was the view of Galen from the 2nd century A.D. I might recall to you that these theories relied on the Platonic ideas of physiology, where pneuma (air) was modified by different organs for the various requirements within the body. <> The liver combined air with digested food and produced the ingredients for growth and nutrition to be distributed by the venous system, while the heart utilized the arterial system to distribute heat as along with pneuma to envivify the body. The brain produced the necessities required for sensation and movement, distributed throughout the body by the nerves. <> Relying upon ingenious experimentation, Galen rejected the ancient idea that arteries contained only gaseous material. Instead, Galen held that upon diastole the arteries drew air in through pores on the skin, mixing it with blood drawn in from the veins. After being used in the body, the spent air or “sooty vapor” was then passed through the septum of the heart into the left ventricle, carried to the lungs, to be there expunged. (Magner, 90-93). Galen’s remained the principal theories for the next 13 centuries, and gained such respect that they were revered as nearly Holy Writ.

Harvey’s Predecessors

<>The Medical Renaissance of the 15th Century brought “admiration for all things Greek” (Porter,Greatest, 169). The original Greek texts were sought, clean of Arabic or Latin interpretation. 1525 brought a Galenic codex published in Greek, paving the way, along with other Greek works, for physicians and researchers of the modern natural philosophy to question the conflicts between these two.

One such critic came in the mid 16th Century; Vesalius, trained by a conservative Galenic advocate, studied anatomy and dissection. “Vesalius grew . . . critical. {His} Familiarity with human anatomy drove him to the unsettling conclusion that Galen had dissected only animals . . . no substitute for human [cadavers]. He now began to challenge the master [Galen] on points of detail” (Porter, Greatest, 179). Vesalius, in Book VI of Fabrica, explicitly denies the permeability of the heart’s septum to allow for the transfer of the sooty vapors as described in the Galenic model, thus clearly weakening the Galenic model of physiology. This work was continued by Vesalius’s successor, Realdo Colombo, in a similar fashion.

<> Colombo, a respected surgeon, took Vesalius’ post as Professor of Anatomy and Surgery at the University of Padua. He continued in the work of Vesalius in presenting questions regarding the Galenic models, but he made a very large, and very public, break with Vesalius, until their relationship became quite tainted. By pointing out Vesalius’ shortcomings, Colombo sought to bolster his own reputation. Colombo’s major work, published in 1559 was an anatomical text wherein he argued against the Galenic idea of blood and pneuma mixing in the right ventricle, his reasoning based on a logical analysis of the size of the components, namely the lungs, right ventricle, and the pulmonary artery. Instead, he presented what we now recognize as the pulmonary circulation, where the blood flows from the right side of the heart, through the pulmonary artery into the lungs and through the pulmonary vein into the left side of the heart (Magner, 190; Porter, Illustrated, 158).

<>Hieronymus Fabricius, Harvey’s mentor at the University of Padua, also made notable progress in anatomy, notably in embryology and the discovery of venous valves, which he published in 1603. He assumed that the valves’ physiological function was to retard the flow of blood so that distribution would be symmetric throughout the body, thus regulating volume instead of direction. (Porter, Greatest, 192-193).

Wm. Harvey

<> This milieu of ideas was present as William Harvey was receiving his education and training. Starting his training in medicine at Gonville & Caius College, Cambridge, Harvey received an Aristotelian education, considered quite archaic and outdated by the rest of the contemporary medical community (French, 51). He then left Cambridge for Padua, “the natural choice for an able and ambitious medical student. A Paduan degree was recognised . . .[as] it was the most famous medical school in Europe” (French, 59-60). Thus, from his Cambridge education steeped in natural philosophy and his cutting-edge medical training in Padua, Harvey was a hybrid from two different worlds. Whitteridge quotes Ent’s early translation of Harvey, where Harvey notes that his world view was clearly framed by the work of those giant’s whose shoulders he was climbing onto:

“. . . know I tread but the steps of other men who have lighted me the way, and (so farre as is fit) I make use of their notions. But in chief, of all the Ancients, I follow Aristotle; and of the later Writers, Hieronymus Fabricius ab Aquapendente, Him as my General, and this as my Guide.”

<> One of the steps that “lighted the way” for Harvey, according to Robert Boyle, was the discovery of the venous valves by his predecessor. This acted as a spark that turned him towards the search for an acceptable physiological answer to a picture murky with ancient ideas (Whitteridge,Movement, 27). He wrote:


“I do not profess either to learn or to teach anatomy from books or from the maxims of philosophers but from dissections and from the fabric of nature” (38).

As the above mentioned discoveries were presented in the medical world, Harvey, true to this statement, evidently repeated the experiments himself, using the “body” as his educator and authority, rather than relying on books written elsewhere. Though Harvey found the same experimental results with the venous valves, he came to very different conclusions. Harvey argued against the explanation of venous valves acting to prevent pooling of blood in the legs and feet, pointing out that the jugular veins’ valves are oriented in the opposite way. Harvey began to reason that the purpose might not be to “retard flow” but to create a unidirectional flow. Later experimentation was to prove his ideas correct (30).

I might recall to you that Harvey’s experimental research that led to the introduction of his theory of general circulation in 1618 was extensive and spanned nearly twenty years. <> He realized, by a logical argument he presents in chapter 9 of De motu cordis, that the heart pumps, by his conservative calculations, three and a half pounds of blood in one half of an hour, while the whole body only contains, upon inspection, four pounds (Franklin, 62). Many other experiments were conducted. <> Harvey proved the unidirectional nature of the venous valves with his famous ligature experiments by manually pushing the blood out of the vein and demonstrating that it could not be forced past a venous valve in a direction distal to the heart. <> He beautifully detailed these findings. <> He surmised a connection between the arterial and venous systems by noting a pulse remained and the veins grew when a tourniquet was placed upon an arm. By turning to “the Book of Nature” and performing his many vivisections and dissections, inspecting anatomy and noting the movement of the heart and blood vessels, Harvey came to conclusions which contradicted the Galenic model. Harvey was then able to utilize the rich array of ideas and observations that had been provided, <> offering up his own theory of general circulation which he published as De Motu Cordis, the writing served the “same purpose as modern scientific article[s]” where the world is informed of new findings and invited to test the theory (Movement, 13). His formal treatise arranges the argument into an exhaustive description of his observed data, presentation of the hypothesis in chapter eight, followed by proof by demonstration, logical arguments, and arguments e consequentia (predictions) and a posteriori (explanations of previous findings) (39).

<> However, though Harvey did present the idea of the general circulation of the blood, it is important to note that the current modern model differs in many key points from that put forward by Harvey in the 17th Century. The physiology behind Harvey’s model is quite similar to that of Aristotle: the distribution of heat throughout the body. The purpose of the heart, while including that of the actual movement of the blood throughout the body, was principally to envivify the blood, bestowing it with some essential quality which it would distribute to the tissues. In the extremities the blood would “coagulate,” and cool, requiring a return to the heart to repeat the cycle. The cause of the heart’s beat was mystical, as well, ultimately springing from the soul. (The modern model, of course, is one of distributing nutrients and other essentials to the tissues of the body and removing the wastes of the processes of life, with a chemo-electric cycle causing the beating of the heart). Harvey’s early education at Caius College is important to remember; Aristotle’s ideas were embedded deep within Harvey, and he held with the idea of the spiritual driving force within the heart and blood being the essential component of the blood and the point for its circulation, with the idea of the blood moving, “as it were, in a circle” featuring prominently as well. Hence, although Harvey put forward the modern idea of continuous circulation, it is also important to note the mystical, Aristotelian physiology he associated with it.

<> What effects did Harvey’s research have upon the world of medicine? His own practice was to suffer, as patients were frightened of new ideas then as well; but of the bigger picture the view becomes murky. Harvey’s scientific approach smacks of the new scientific method that was soon to become a driving force, but in Harvey’s case the roots are more ancient Aristotlean and Galenic in origin than a foreshadowing of “new science.” There were plenty of reactionary writings, both opponents and proponents, so we can certainly say Harvey’s work stirred scientific discussion. <> Ultimately, however, the influence of Harvey was in the attack upon Galenic physiology, not in his contribution to medical knowledge of cardiology (Conrad et. al, 338-9).

Modern Medicine’s Myopia

<> Harvey’s proposal of continuous circulation of the blood forms a fine example of scientific progress; he used the findings of those before him, examined them and, discarding those he found unworthy, kept only those he found accurate. Occasionally, the opposite can happen, and an article from the Journal of the American Medical Association in 1903 is illustrative of this point. <> Allow me to briefly digress in my introduction of this topic to discuss two interesting words. First, phalacrophiba – somewhat irrational as it is, <> the word describes the fear (known primarily by men in their twenties) of becoming bald. The second word, peladophobia, seems to describe a more logical fear,<> as it describes the fear of bald people themselves. Returning to the 1903 JAMA article entitled “Prophylaxis of baldness,” the introduction follows: <>

“If anyone had insisted 25 years ago that tuberculosis was only slightly hereditary, but distinctly communicable, they would have been laughed at. The germ theory has now become a doctrine of ever-widening scope, and we realize that many affections are directly communicable and only a few hereditary. At the present moment it seems that even for so old-fashioned an affection as baldness a complete change of opinion as regards etiology is taking place. As with tuberculosis, so it has long been noted that baldness is likely to run in families.”

<> The author goes on to cite findings that premature baldness is “practically always associated with the presence of certain bacteria” and then suggests a causative relationship, further hypothesizing that “undoubtedly the ordinary conditions of scalp hygiene among men are favorable to the development of these germs” and that the relative ischemia caused by hatbands may play a role as well, possibly by decreasing the ability to combat the microbes mentioned above.

<> As an exemplary clinician, the author’s principal concern appears to be for his patients. He counsels:

“Greater care should be taken with regard to brushes and combs, especially in families in which early baldness is the rule. The hair brush should be dipped in an antiseptic solution several times a week. Combs should be boiled regularly and frequently, and under no circumstances should members of precociously bald families use other combs or brushes than their own, or allow them to be used on them, in barber shops, unless they are assured of their sterilization beforehand. These precautions may seem a high price to pay for the prophylaxis of premature baldness, and many will prefer to take the chance of becoming bald, but some have such a horror of the affliction that they will willingly put themselves to much trouble to prevent it.”

While we are able to now, with the support of more than 100 years of scientific progress, find this line of reasoning and counsel humorous, it does offer an important point. New findings are being interpreted by people living in a world steeped with ideas, opinions, and “facts.” This is why progress must be met with skepticism. Not all of the “facts” are actually factual; certainly not all that is written is true. Personal observation of, as Harvey put it, “The Book of Nature,” should not so easily be replaced by new discoveries.

To turn to a more modern (and more medical) example, the history behind the approach to peptic ulcers is illuminating. <> First described by William Brinton in 1857, the lesion was accurately detailed along with its accompanying symptoms of pain, vomiting, and occasionally hemorrhage. Brinton’s conjectures as to etiology were quite varied and had an impressive scope, including “old age, privation fatigue mental anxiety, and intemperance” (Grob, 551). <> As time passed the consensus became an excess of acid as the primary factor, but this merely displaced the search for a cause to what was causing the acidification. Grob notes that “the absence of evidence that could relate causes to disease processes did not prove a deterrent. Physicians instead drew upon prevailing medical paradigms and external social and ideological belief systems to develop what appeared to be defensible etiological explanations” (Grob, 557). Such explanations included focal infection, leading to many extractions, appendectomies, colectomies and colostomies, although this explanation fell out of favor in the 1930s as no causative organism could be isolated; <> stress and psychic factors also featured prominently, with “shell shock” and the increasing demands of the industrialized world pointed to as evidence; racial factors were also considered, as one physician noted a relative dearth of ulcer disease in the African-American population, writing that it was due to the “slow-moving” and “easy-going [nature] . . . untouched by aspiration for culture.” (560)

Of course, our current understanding of peptic ulcer disease is not perfect; while the etiology is now attributed to infection with H. pylori or NSAID use, only a fraction of patients with these risk factors develop symptoms. <> Grob, however, points out that “medical explanations and therapies . . . do not always follow from rational scientific discovery, and conflicts between medical specialties, prevailing medical and scientific paradigms, ideological beliefs, and personal allegiances affect the manner in which diseases are interpreted and treated. . . To point this out is not in any way to denigrate biomedical science . . . it is merely to remind practitioners that it would be wise to recognize the contingent nature of etiological explanations and therapies.” (564). Although we strive to live a higher law, we must remember that physicians and scientists are, after all, human as well and subject to all of the interpretation flaws that history has shown us. By recognizing these flaws, we can be watchful for them and thus be able to provide better care for our patients.

Conclusion

<> With the benefit of three hundred years of scientific progress, the significance of Harvey’s discovery could be either exaggerated or minimized. His courage in tackling the Galenic fortress, though it had been softened by those before him, was immense; critics, on the other hand, could cite his inability to dispense with the mystical ideas of Aristotle as his downfall. Regardless, Harvey has influenced medicine by breaking the foundation of Galenic physiology as noted in his writing, “I do not profess to learn or to teach anatomy from books or from the maxims of philosophers butfrom dissections and from the fabric of nature.” As long as we, as clinicians, can also remember to interpret new ideas with a sense of transference and counter-transference towards the new research, we can look at Harvey’s great contribution as providing yet another, greater height whose new vista will beckon to the generations to come as they go forth on their own quests for truth.



Bibliography

Conrad, Lawrence, Michael Neve, Vivian Nutton, et. al. The Western Medical Tradition. Cambridge, England, Cambridge University Press, 1995.

French, Roger. William Harvey's Natural Philosophy. Cambridge, England, Cambridge University Press, 1994.

Grob, Gerald. The Rise of peptic ulcer, 1900-1950. Perspectives in Biology And Medicine2003;46(4):550-66.

Harvey, William, Gweneth Whitteridge, ed., De Motv Locali Animalivm. Cambridge, England, Cambridge University Press, 1959.

Harvey, William, Gweneth Whitteridge, ed., The Movement of the Heart & Blood. Blackwell Scientific Publications, Oxford, England, 1976.

Harvey, William, Kenneth Franklin, ed. The Circulation of the Blood and Other Writings. J.M. Dent & Sons, Ltd., London, England, 1979.

JAMA 1903;40:249 as quoted in JAMA 2003;289(4):494

Magner, Lois. A History of Medicine. New York City, New York, Marcel Dekker, Inc., 1992.

Porter, Roy. Cambridge Illustrated History of Medicine. Cambridge University Press, Cambridge, England, 2001.

Porter, Roy. The Greatest Benefit of Mankind. Harper Collins Publishers, Ltd., NYC, USA, 1997.

Whitteridge, Gweneth. William Harvey and the Circulation of the Blood. MacDonald, London, England, 1971.


Sunday, March 14, 2010

On Honesty and Dating, or, This Mormon Life

My friend Chris had the idea to try and create a Mormon analogue for the amazing radioshow, This American Life. To that end, he created a group blog that explores a single topic each week. The topic is dealt with by a variety of individuals, all of whom hopefully approach it in a different and creative way. Last month was a discussion of honesty and dating, particularly in the Mormon sphere. While the discussion takes place with that narrow scope, I think most of the principles are applicable whatever your personal creed. Anyway, since I haven't posted anything substantial for some time, here is my bit from last month. If you do have comments, which I would love to hear, I would ask that you please post them over at the website where the original article was posted. I think you might enjoy the blog.

On Honesty & Love in Dating

David Sedaris has a lot of stories about hitch-hiking. He said it started out as an easy way to get to the other side of town, then became a cheap way to get to the next city, and then became a way to enjoy the thrill of being able to recreate himself. With every new driver he got the chance to fashion a new identity, an opportunity to become someone more interesting; someone more exciting; someone more, well, new.

One of the places that it is easiest to become someone new is, of course, the internet. Take, for example, the first girl I ever chatted with over a modem. Back in the days of BBS’s and direct computer-to-computer connections, we met and chatted about various things. Eventually she sent me a picture of herself, really without prompting.

While everyone on the internet is obviously not a liar or sexual predator, it does become very easy to misrepresent yourself and be dishonest. I was recently at a coffee shop with my friend Linezolid.1 She, along with about fifteen other friends, has been telling me I should look into the world of online dating. The implications of this on my personal life are best saved for another day. This did, however, lead to a very interesting conversation about dating. She told me of an older man she came across on one of these sites. His profile was different because, well, it candidly disclosed the fact that he had a sexually transmitted infection. One of the permanent kinds. I did not ask if it was as serious as HIV or as (relatively) benign as genital warts, but that is really beside the point. What was interesting was that he was so candid, so up-front and open about it. Almost in-your-face about it. While his staunch rejection of the easy opportunity to be dishonest is laudable, was this stark honesty the right approach? Sooner or later, the woman he ends up in a relationship with will find out, anyway. Hopefully from him, and not from her physician. If the disease was going to be a deal-breaker in itself, we figured he was probably just trying to weed those people out early. Really early. Before even meeting.

But what if it was not going to be a deal breaker? How many people would this early disclosure, this preemptive strike, drive away too early? How many that, after knowing him better (or at all) would have otherwise still accepted him, warts and all?2 After all, none of us are perfect. Such blunt honesty is not only awkward, it is almost dishonest in itself. Are there others on this online dating site whose profiles include “anger issues” or “horrible with directions?” “Compulsively late” or “commitment issues?” Before knowing someones shining points, how can you really judge their weakest ones? If there is such a thing as too much honesty, I think this is it.

But isn’t that basically the point of dating? I mean, dating seems like some sort of complicated dance where we slowly reveal portions of ourselves to each other as we become more and more intimate. And I do not mean intimate in a necessarily sexual way, but rather the real intimacy. The intimacy only reached by sharing time together, talking, learning each others’ secrets, and holding those secrets close. Becoming aware of how the other person thinks, feels, and lives – that is intimacy. In that way, I believe that Internet-Guy-With-An-STD was on the right track, but jumped the gun. He was trying to be completely honest, but a bit too soon. At least of this sort. While he has probably had good reason to do so, likely by being hurt in the past because of late disclosure, he is skipping steps in the dating process, revealing too much, too quickly. And those steps are there for a reason. Maybe presenting your best face, which some may call lying, is not only appropriate but often necessary in dating. Dating etiquette requires phased honesty.

In unrelated conversations with a few other friends, the issue of honesty and dating was repeatedly brought up with specific regards to faithfulness within Mormonism. As many of you know, there are, in fact, varying degrees of Mormons within our community. There are Iron-Rods and Liahonas, there are the EQPs and FEQPs.3 There are Peter Priesthoods, Molly Mormons, and Jack Mormons. There are True Blue Mormons and Cafeteria Mormons.4 It is with some of these last type, friends who are quiet (and active) cafeteria Mormons, that this idea of honesty and dating has come up frequently. And the conversation usually gets pretty heavy, pretty quickly. I mean, what would you say if someone asked you, “Do I need to tell her that I don’t believe in revelation?” or, “How early should I tell my boyfriend/girlfriend that I can’t support the Church’s policy on Proposition 8 [or the stance on the role of women, or whatever]?” or “I may go to church every Sunday, but I don’t believe in God the same way everyone there does. When should I tell him that?” Is there a right answer to those types of questions? I didn’t think so either.

Another friend, Ember1 thought these dilemmas of faith (or lack of faith) an absolutely essential subject for discussion, at least as relating to relationships and Mormonism. Bishops, home teachers, or anyone else besides a boyfriend/girlfriend, are another matter. To her it was simply a matter of timing, not an option of whether or not to have the discussion at all. How early, though,one should “drop the bomb” was a little less clear. Should this timing relate to kissing? To dating exclusively? To discussion of marriage? The conclusion was that you should tell them as soon as you (or the significant other) starts to think seriously about the relationship.5

It seems, to me at least, that uber-bluntness is not quite the right approach. But neither is persistent deceit, whether by creating a new persona or hiding your true one. I think they both fail in relationships because they prevent that intimacy, that closeness, from forming. David Sedaris has a lot of stories about hitch-hiking. He said many of the stories involve lying through his teeth. He said that the feel of the cold gunmetal against his head felt exactly like he thought it would. He said that after the second time he had a gun pulled on him, he gave up hitch-hiking all together. Maybe he should have just tried being more honest while hitching. Then maybe he wouldn’t have had people lying to him, too. He might have even found someone who would drive him around for eternity.



  1. Name changed to protect identity or somesuch.
  2. Sorry. Horrible, I know. I couldn’t resist.
  3. Elders’ Quorum Presidents and Future EQPs.
  4. A cafeteria Mormon is one who chooses which teachings to believe, a la carte style. Not my term.
  5. In Ohio terms, I believe this is also known as “the first date.”

Wednesday, March 3, 2010

Way cooler than the Fonz

Seriously, is there a band cooler than OK Go!? I'm not necessarily talking about their music. I'm willing to bet everyone has seen some of their music videos (which they direct, by the way), and many have read the NYTimes OpEd piece by them about the music industry, but their latest video is really amazing. I was laughing and smiling through almost the whole thing - I felt like Charley getting his first glimpse of the Chocolate Factory.




For those of you who have missed their older ones, here are a couple. I haven't really watched the remixes of the WTF video - anyone have favorites?